{"id":2069,"date":"2020-08-11T10:11:44","date_gmt":"2020-08-11T10:11:44","guid":{"rendered":"https:\/\/bioport.ee\/thefirst-visible-and-also-most-striking-sign-of-skin-aging-is-the-increased-wrinkling-of-the-face-neck-and-the-area-around-the-eyes\/"},"modified":"2020-08-25T12:14:28","modified_gmt":"2020-08-25T12:14:28","slug":"botuline","status":"publish","type":"page","link":"https:\/\/bioport.ee\/en\/botuline\/","title":{"rendered":"Botuline"},"content":{"rendered":"\t\t
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The\tfirst visible and also most striking sign of skin aging is the increased wrinkling of the face, neck and the area around the eyes.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The formation of wrinkles on the skin is mainly due to the following factors:<\/span><\/p>\n

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  • Aging<\/b><\/li>\n
  • Contraction of facial muscles, caused by repeated <\/span>facial expressions<\/b><\/li>\n
  • Exposure to <\/span>U<\/b>ltra <\/span>V<\/b>iolet (UVA & UVB), Infrared (IR) and <\/span>H<\/b>igh <\/span>E<\/b>nergy <\/span>V<\/b>isible (HEV) radiation (<\/span>photo-aging<\/b>)<\/span><\/li>\n
  • e <\/i><\/b>-aging<\/i><\/b>, the negative e ect on the structural integrity of the deepest skin layers of<\/span> electromagnetic radiation<\/span><\/i> (EMR) and<\/span> B<\/i><\/b>lue<\/span><\/i> L<\/i><\/b>ight<\/span><\/i> emitted from all electronic devices (cell-phones, computer screens, laptops, tablets, TV sets, WiFi, microwaves etc)<\/span><\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/section>\r\n\t\t\t\t
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    • Aging occurs naturally over time and is identified by speci c biochemical, histological and physiological changes. The dermis becomes thinner for two reasons. The rst reason is the reduction in the number of broblasts, which produce the essential macromolecules of the extra cellular matrix (collagen, elastin, bronectin etc). The second reason is the reduced power of broblasts to produce those macromolecules.\n

      <\/span>At the same time, alterations of the collagen mesh lead to the formation of the rst wrinkles on the skin. Therefore, it is very important to protect the existing collagen bers and reactivate the dynamics of new structural tissue generation, in order to delay the aging process.<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t

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      • When we express our emotions, by laughing, crying, smiling, frowning, eyeblinking, our subcutaneous muscles contract thousands of times every day. These repeated movements create tension forces that modify the dermis and favor the appearance of expression wrinkles, especially around the mouth, on the forehead and around the eyes.\n

        <\/span><\/li>\n

      • Exposure to sun radiation is a well-known factor related to the premature aging of the skin and the formation of wrinkles. Sun radiation causes oxidative stress (over-production of free radicals) in the dermis, resulting in suppression of the immune system of the skin and destru-<\/span><\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t
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        ction of broblasts which are essential for the integrity of the connective tissue and consequently for the appea-rance of the skin.<\/p>\n

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        • e<\/i><\/b>-aging<\/i><\/b>, <\/span>the latest<\/span> and <\/span>rapidly increasing<\/span> concern, is the <\/span>negative effect of the electromagnetic radiation<\/span><\/i> (EMR) and <\/span>Blue Light <\/span><\/i>emitted from all types of electronic devices.<\/span> Waves of electronic pollution constantly attack our skin and penetrate deeper than solar radiation. They cause <\/span>massive oxidative stress<\/span> resulting in intensi ed cutane-ous fatigue, microcirculation slow down, dark eye circles, eye bags, decrease of skin cohesion, skin regeneration slowdown, dull complexion and <\/span>excessive wrinkling<\/span><\/i>.<\/span><\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/section>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/section>\r\n\t\t\t\t
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          BOTULINE: Total anti-wrinkle management system<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/section>\r\n\t\t\t\t
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          Based on a <\/span>powerful combination <\/span>of biomimicking peptides and innovative active ingredients<\/span><\/p>\n

          BOTULINE <\/b>is the <\/b>total<\/i><\/b> anti-wrinkle <\/b>management system<\/b><\/p>\n

          which\u00a0 ghts all <\/span>four<\/span> main causes of the formation of wrinkles.<\/span><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/section>\r\n\t\t\t\t

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            \n
          • Palmitoyl Tripeptide-1 & Palmitoyl Tetrapeptide-7<\/b>:<\/span> two biomimicking peptides called \u201cMatrikines\u201d, cell messengers of cutaneous reconstruction and repair. They stimulate production of collagen and elastin in broblasts. Collagen is the main constituent of the connective tissue, with pivotal role in the aging process. By stimulating collagen production we ght skin aging in depth, reconstructing the extra cellular matrix. Wrinkles, even the deepest ones, become visibly reduced.<\/span><\/li>\n
          • Acetyl Hexapeptide-8 & \u0391cetyl Octapeptide-3: <\/b>two<\/span> biomimicking peptides composed of natural aminoacids. They inhibit the excessive release of acetylcholine that commands muscle contraction. Thus, they favour the relaxation of expression muscles and prevent or correct the wrinkles caused by repeated facial expressions. They are non-aggressive, completely safe alternative to other existing, complicated methods, without any side-e ects or injections.<\/span><\/li>\n
          • Nasturtium O\ufb03cinale Extract: <\/b>a plant extract, rich in<\/span> inorganic compounds that prevents the transmission of contraction orders, by limiting the in ux of sodium into muscle cells. As a result, it inhibits the contraction of myo brils, favouring the relaxation of expression muscles and corrects wrinkles caused by facial expressions.<\/span><\/li>\n
          • CM-Glucan, Phytosphingosine, Venuceane, Diamino-propionoyl Tripeptide-33: <\/b>three active ingredients in combination with a biomimicking peptide e ectively ght wrinkles caused by photo-aging.<\/span><\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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            -CM-Glucan: <\/b>natural polysaccharides which stimulate <\/span>skin\u00b4s own defense mechanism, promote cell renewal, <\/span>reduce any kind of irritation, o ering protection against UV <\/span>induced oxidative stress (photo-aging).<\/span><\/p>\n

            -Phytosphingosine: <\/b>blend of natural ceramides with <\/span>strong anti-in ammatory activity. It suppresses the release <\/span>of cytokines which cause degradation of the extra cellular <\/span>matrix of the skin, resulting in<\/span> ne lines and wrinkles. It <\/span>reduces any in ammation related to UV exposure, <\/span>minimizing the visible signs of photo-aging.<\/span><\/p>\n

            -Venuceane: <\/b>an active ingredient of marine origin, a free<\/span> radical scavenger of new generation. It is activated when the skin needs intensive care (during exposure to every day UV radiation and aggressions), o ering protection of epidermal cells, broblasts and DNA against UV-induced lesions.<\/span><\/p>\n

            -Diaminopropionoyl Tripeptide-33: <\/b>protects cells from<\/span> UVA-induced DNA damages and promotes the DNA repair system of skin cells.<\/span><\/p>\n

              \n
            • Alpha-Glucose & Lespedeza Capitata Leaf\/Stem Extract: <\/b>two contemporary actives of natural origin.<\/span> Forming an innovative biocomplex with stunning anti-oxidant power, drastically protect and prevent from <\/span>e <\/i><\/b>-aging<\/i><\/b>, neutralizing the oxidative stress caused by<\/span> electromagnetic radiation <\/span><\/i>(EMR) and<\/span> B<\/i><\/b>lue <\/span><\/i>L<\/i><\/b>ight <\/span><\/i>emitted<\/span> from all types of electronic devices.<\/span><\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/section>\r\n\t\t\t\t
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              BOTULINE Treatment<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/section>\r\n\t\t\t\t
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              Botuline Visage (face cream)<\/b><\/p>\n

              Visibly reduces ne lines and wrinkles caused by <\/span>aging<\/span><\/i> and <\/span>facial expressions <\/span><\/i>with the revolutionary combination of<\/span> state-of-the-art biomimicking peptides Acetyl Hexapeptide-8, Acetyl Octapeptide -3, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7 and Nasturtium O cinale Extract.<\/span><\/p>\n

                \n
              • Prevents and fights wrinkles caused by <\/span>photo-aging<\/span><\/i>, with the biomimicking peptide Diaminopropionoyl Tripeptide-33 and CM-Glucan, which stimulate skin\u2019s own defense mechanism.<\/span><\/li>\n
              • Protects and prevents from <\/span>e<\/i><\/b> -aging<\/i><\/b>, thanks to the remarkable anti-oxidant power of the innovative biocomplex of Alpha-Glucose and Lespedeza Capitata Leaf\/Stem Extract.<\/span><\/li>\n
              • Increases skin elasticity and moisturization.<\/span><\/li>\n
              • Hypoallergenic.<\/span><\/li>\n
              • Clinically tested.<\/span><\/li>\n<\/ul>\n

                Apply every day and night, as your daily facial anti-wrinkle cream. Apply over face and neck focusing on the most wrinkled areas of your skin (around the mouth and on the forehead).<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t

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                  Botuline Yeux (eye cream-gel)<\/b><\/p>\n

                  Remarkably reduces ne lines and wrinkles on the area around the eyes (crow\u2019s feet), caused by <\/span>aging<\/span><\/i> and <\/span>facial<\/span><\/i> expressions <\/span><\/i>with the innovative combination of the state-of-the-art biomimicking peptides Acetyl Hexapeptide-8, Acetyl Octapeptide -3, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7 and Nasturtium O cinale Extract.<\/span><\/p>\n

                    \n
                  • Prevents and fights the formation of wrinkles on the extremely sensitive area around the eyes, caused by <\/span>photo-aging<\/span><\/i>, with the biomimicking peptide Diaminopro-pionoyl Tripeptide-33 and Phytosphingosine, which is the most e ective anti-in ammatory active.<\/span><\/li>\n
                  • Protects and prevents from <\/span>e<\/i><\/b> -aging<\/i><\/b>, thanks to the remarkable anti-oxidant power of the innovative biocomplex of Alpha-Glucose and Lespedeza Capitata Leaf\/Stem Extract.<\/span><\/li>\n
                  • Increases skin elasticity and moisturization.<\/span><\/li>\n
                  • Hypoallergenic.<\/span><\/li>\n
                  • Ophthalmologically tested.<\/span><\/li>\n<\/ul>\n

                    Apply twice daily, with light massaging motions, on the area around the eyes.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t

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                      \r\n<\/ul>\r\n<\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/section>\r\n\t\t\t\t
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                      Botuline Serum\u00a0<\/b>(concentrated formula for face & eyes) A concentrated formula for the most e ective treatment of wrinkles caused by aging and facial expressions, even the deepest ones, based on the combination of state-of-the-art biomimicking peptides Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7 and Nasturtium O cinale Extract.<\/p>\n

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                      • Prevents and fights wrinkles caused by photo-aging with the biomimicking peptide Diaminopropionoyl Tripeptide-33 and Venuceane, which o er protection of epidermal cells and broblasts.<\/li>\n
                      • Protects and prevents from e -aging, thanks to the remarkable anti-oxidant power of the innovative biocomplex of Alpha-Glucose and Lespedeza Capitata Leaf\/Stem Extract.<\/li>\n
                      • Increases skin elasticity and moisturization.<\/li>\n
                      • Hypoallergenic.<\/li>\n
                      • Ophthalmologically tested.<\/li>\n<\/ul>\n

                        Apply Botuline Serum on your face, neck and eye area, before the application of Botuline Visage or Botuline Yeux respectively and enjoy optimum results.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t

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                          Proof of e\ufb00ectiveness<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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                          Clinical studies* prove the impressive action of the Botuline anti-wrinkle treatment.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/section>\r\n\t\t\t\t

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                          Depth of wrinkles<\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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                          -37%<\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t

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                          Number of wrinkles<\/b><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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                          -48%<\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t

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                          Moisturization<\/b><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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                          +46,5%<\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t

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                          Skin Elasticity<\/b><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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                          +100%<\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/section>\r\n\t\t\t\t

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                          *Results after use of Botuline Visage and Botuline Yeux twice daily for 60 days.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/section>\r\n\t\t\t\t

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                          BOTULINE Colorceuticals: All day maquillage + treatment + sun protection<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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                          Three innovative products specially formulated to combine 3 actions in 1 product:<\/p>\n

                            \n
                          • Excellent, long lasting, natural looking, velvety coloring e\ufb00ect, based on waterproof, oil-free formulas with microspheres that reflect light for additional radiance.<\/li>\n
                          • Total anti-wrinkle action, based on formulas enriched with Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Nasturtium O cinale Extract and Alpha-Glucose.<\/li>\n
                          • Safe and e\ufb00ective sun protection, based on innovative formulas guaranteeing very high SPF 50+ and protection from UVA\/UVB\/IR\/HEV (High Energy Visible).<\/li>\n<\/ul>\n

                            Botuline Colorceuticals are ideal for daily use, from morning to night to complement and enhance the anti-wrinkle action of the Botuline Treatment products while rendering a perfect complexion!<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/section>\r\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

                            The first visible and also most striking sign of skin aging is the increased wrinkling of the face, neck and the area around the eyes. The formation of wrinkles on the skin is mainly due to the following factors: Aging Contraction of facial muscles, caused by repeated facial expressions Exposure to Ultra Violet (UVA & […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"footnotes":""},"class_list":["post-2069","page","type-page","status-publish","hentry"],"yoast_head":"\nBotuline - Bioport<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/bioport.ee\/en\/botuline\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Botuline - Bioport\" \/>\n<meta property=\"og:description\" content=\"The first visible and also most striking sign of skin aging is the increased wrinkling of the face, neck and the area around the eyes. 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